Neuro-MEP-Micro-V

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Neuro-MEP-Micro-V is a very versatile instrument that allows performing almost all Electromyography (EMG), Nerve Conduction Studies (NCS), and Evoked Potentials (EP) tests on one dedicated platform.

 

It combines the exceptional sophistication and simplicity to use – due to advanced technologies developed with the research and clinical progress in the field.  The intuitive interface allows focusing on the job assessing your veterinary patients more accurately and conducting experimental research with high precision and reproducibility.

 

Neuro-MEP-Micro-V key features:

 

· 2 recording channels optimized to perform quickly motor and sensory conduction tests, needle EMG.

 

· Portability, operating with a notebook computer.

 

· All-in-one design:  Stimulators, acquisition channels, controls, and display.

 

· High quality of signal acquisition:  Sampling rate – up to 100 kHz.

 

· Electrical stimulator with ultra-fast switching between two outputs.

 

· Operation in electromagnetically unshielded environments – no shielding required.

 

· Intra-operative monitoring during surgery and recovery, and experimental research.

 

· Data export to Excel and other statistical software for further statistical analysis.

 

· Extensive database, HL7 compatibility.

Portable excellence

 

Neuro-MEP-Micro-V, despite its compact design, allows performing almost all EMG, NCS and EP tests on one dedicated platform for clinical assessments and experimental research:

 

· NCS – Nerve Conduction Studies:  Motor and sensory conduction velocity, F-wave, H-reflex, motor and sensory inching.

 

· EMG – Electromyography:  Spontaneous activity, interference curve, motor unit potentials (MUP), macro EMG.

 

· Neuromuscular junction testingRepetitive stimulation, jitter.

 

· Motor Unit Number Estimation (MUNE).   

 

· Additional EMG tests:  Blink reflex, sacral reflex, bulbocavernosus reflex, Т-reflex (with optional tendon hammer), galvanic skin response.

 

· Evoked potentials:

o Somatosensory Evoked Potentials (SEP).

o Visual Evoked Potentials (VEP) – with optional photic stimulator.

o Auditory Evoked Potentials (AEP) – with optional ear phones.

o Vestibular Evoked Myogenic Potentials (VEMP) – with optional ear phones.

 

2 Channels optimized to perform quickly Motor and Sensory Conduction Tests, Needle EMG

 

97% of all EMG tests are done with the use of one channel.  Channel 1 is set by default to connect electrodes for motor conduction measurement, and Channel 2 is used to plug in electrodes to measure sensory conduction.

 

Such channel separation speeds up performing the exams.  As soon as the motor conduction velocity is measured, the user can run sensory conduction velocity test, and program will start the response acquisition using the Second Channel.

 

Two recording channels

 

While most of EMG tests are administered in a single channel, two channels significantly improve workflow and speed up assessments:  The two recording channels are optimized to record motor and sensory nerve conduction velocity (CV) and needle EMG tests simultaneously. 

 

By default, the first channel is intended to plug in the electrodes for M-wave testing, while the second one is designated for electrodes used for sensory nerve conduction velocity during NCS. 

 

This channel configuration allows considerable saving of examination time.  Upon motor CV-test completion, run a sensory CV test, and the software will run automatically the second test using Channel 2.

 

Two software-switchable outputs for electrical stimulator electrodes

 

Two pairs of stimulating electrodes can be placed on the veterinary patient, and either of them can be used for stimulation – switched from software.

 

Thus, there is no need to physically re-connect the electrodes.

 

Dedicated keyboard

 

Neuro-MEP-Micro-V features a designed keyboard that gives an easy access to all main functions – adjusting stimulus, starting stimulation, add data to analysis, etc. – without changing the hand position.  All required controls are always at your fingertips.

 

The built-in miniature graphic monitor allows controlling stimulation parameters, as well as checking electrode placement quality during the test.

 

Speed and ease of use:  All-in-one stimulators, acquisition channels, controls, display

 

Thanks to a built-in keyboard, EMG studies are simple and fast.  On average, an experienced specialist performs standard EMG study 1.5 times faster with such keyboard compared with a standard computer keyboard and mouse.

 

The color display shows stimulation parameters and electrode placement quality. With Neuro-MEP-Micro this data is always at hand.

 

High acquisition quality:  Sampling rate – up to 100 kHz

 

High sampling rate and analog-to-digital conversion (ADC) capacity allow obtaining recorded traces of exceptional quality under any circumstances:

 

· Perform acquisition without special grounding, when computer is powered from a common three-wire outlet.

 

· Obtain sensory responses even after the first stimulus (without averaging).

 

Neuro-MEP-Micro-V signal-acquisition channels are optimized to record needle EMG, with immunity to noise considerably increased.  It makes needle-EMG study faster and improves the quality of needle-EMG acquisition.

 

Electrical stimulator with ultra-fast switching between two outputs

 

Two outputs of the electrical stimulator are software-controlled.  They allow placing two stimulating electrodes on a veterinary patient or research veterinary patient and activate them from software.  Thus, during the exam, there is no need to physically switch the electrodes.

 

To attach the stimulating electrode, either touch-proof or DIN connector can be used.

 

Operation in unshielded environments

 

Neuro-MEP-Micro-V is highly efficient – clinically and economically.  It can be used in any unshielded environment and does not require additional expenses for the specialist’s workplace.  This provides comfort both for a specialist and veterinary patient and improves exam performance.

 

Advanced analysis tools

The software provides the clinician or researcher with the necessary tools to analyze recorded responses.

 

Intelligent software with veterinary-specific algorithm

 

The supplied software features a veterinary-specific algorithm.  It ensures EMG recording, calculation of all major parameters, analysis, and report generation.  

 

Exceptionally high-quality low-noise physiological preamplifiers, combined with high-efficiency wide-dynamic-range analog-to-digital conversion, digital filtering, and digital signal-processing algorithms, were specifically designed for Neuro-MEP-Micro-V based on extensive research and development.  They ensure excellent noise suppression, clear signal recording, and reliable, reproducible calculation of recorded parameters.

 

This allows not only better diagnostics, but also reliable monitoring for any changes in follow-up assessments over prolonged periods of time.

 

Intra-operative monitoring

Designed to work in the electro-magnetically harsh OR environment, Neuro-MEP-Micro-V can be used as a reliable intra-operative monitor during surgery and post-operative recovery.

 

Reports

 

Reports – with recorded traces, numeric data, and comments – are generated on-screen, can be saved, printed out, and shared.

 

Database and data export

 

Measurement data and interpretation, as well as exam reports, are saved in a well-organized software database.  The data and reports can be printed out either at the time of the assessment, or at a later time, and shared with a referring doctor or researcher.

 

Recorded parameters can be exported to Excel spreadsheets and other statistical software for further data

analysis making it an ideal tool for research projects.

 

Portability

 

The device is pocket-sized, and can be placed in a Carrying Case – along with a notebook computer – and can be powered from the computer.  Hence, it can be used both in the clinic and on a visit.

 

This means that long-term monitoring system is always at hand no matter where you perform surgery:  at your clinic or at another location.

 

Software compatibility

 

Neurosoft Software enables highly efficient operation – saving both capital and operating costs – through a number of compatibility features:

 

Multiple Neurosoft Software:  Neurosoft Software for various Neurosoft instruments can be installed on the same computer – with no conflict between them.  Moreover, all software can share a single database – for greater convenience and work-flow efficiency.

 

Multiple computers:  Although only one computer can be used for diagnostic test data recording, each Neurosoft Software License allows using software on an unlimited number of computers.  Thus, the data can be recorded on one computer, and then, the data can be shared, analyzed, reviewed on other computers – with no additional Software Licenses.

 

Other applications:  Neurosoft Software can operate on a computer with Microsoft Office applications – Word, Excel, Outlook, PowerPoint, Access, Project, as well as Adobe and accounting software.  This is particularly efficient in smaller clinics.

 

Internet:  Computers with Neurosoft Software installed can be connected to the Internet.  In an unlikely and rare event that a Microsoft Operating System update affects a Neurosoft software component, it can be restored by Neurosoft software re-installation, with no loss of data. 

 

Information system integration

 

Most clinics, networks and research institutions are equipped with information systems to store and process their data.  HL7 (Health Level 7) is the most commonly used interface engine for exchange, integration, sharing and retrieval of electronic data.

 

HL7-compatibility allows integrating Neuro-IOM-16-V into the information system of a veterinary clinic, clinical network, or research institution.

 

Disinfection

 

Electronic Unit – soft cloth gently wrung in phenols (Bacillotex® etc.), or 70% alcohol, or 0.5% chlorohexidine.

 

If dangerous virus contamination is suspected – aldehydes (Cidex® etc.), or chlorinates (Diversol BX® etc.).

 

Interface cables and power cords – soft cloth moistened with disinfectant, for example, 1% chloramine solution or 3% hydrogen peroxide solution.

Biopotentials Acquisition Channels

Number of channels

2

Sampling rate – with Neuro-MEP.NET software

200 Hz40 (160) kHz

A/D converter

16-bit

Input Voltage range

20 µ 50 mV

Ratio error of voltage measurement:

- in the range from 20 up to 100 µV

- in the range from 0.1 up to 50 mV

 

within ±15%

within ±5%

EP voltage range at averaging

0.1 – 400 µV

Ratio error of EP voltage measurement at averaging

within ±10%

Common-mode rejection

≥ 100 dB

Noise level, rms

≤ 0.5 µV

Input impedance

≥ 200/1000 MΩ

Amplifiers input capacitance

≤ 25/22 pF

Patient leakage current:

≤ 0.1 µA

Bandpass flatness:

- in the band from 0.02 up to 0.05 Hz and from 5 up to 10 kHz

- in the band from 0.05 Hz up to 5 kHz

 

from –30 to +5%

 

from –10 to +5%

High pass filter

0.02, 0.05, 0.1, 0.2, 0.3, 0.5, 1, 2, 3, 5, 10, 20, 30, 50, 100, 200, 300, 500, 1000, 2000, 3000 Hz

Low pass filter

10, 20, 35, 50, 75, 100, 150, 200, 300, 500 Hz;

1, 2, 3, 5, 10 kHz

Sensitivity with Neuro-MEP.NET software

0.05, 0.075, 0.1, 0.15, 0.2, 0.25, 0.4, 0.5, 0.75, 1, 1.5, 2, 2.5, 4, 5, 7.5, 10, 15, 20, 25, 40, 50, 75, 100, 150, 200, 250, 400, 500, 750 µV/div;

1, 1.5, 2, 2.5, 4, 5, 7.5, 10, 15, 20, 25, 40, 50 mV/div.

Ratio error of sensitivity

within ±5%

Sweep speed

0.1, 0.15, 0.2, 0.25, 0.4, 0.5, 0.75, 1, 1.5, 2, 2.5, 4, 5, 7.5, 10, 15, 20, 25, 40, 50, 75, 100,

150, 200, 250, 400 ms/div.;

0.5, 0.75, 1, 1.5, 2 s/div.

Suppression ratio of power frequency by notch filter

≥ 40 dB

Electrical Stimulator

Stimulus amplitude

0.1 – 100 mA

Absolute deviation of stimulus amplitude

±0.1 mA

Stimulus duration – with Neuro-MEP.NET software

100 – 50000 µs

Absolute deviation of stimulus duration

±5 µs

Stimulus frequency at repetitive stimulation – with Neuro-MEP.NET software

0.1 – 100 Hz

Relative deviation of stimulus frequency during repetitive stimulation

within ±1 %

Inter-stimuli interval at paired stimulation – with Neuro-MEP.NET software

10 – 100000 ms (0.01 – 100 s)

Burst stimulation – with Neuro-MEP.NET software:

- pulse frequency

- maximum burst duration

 

 

40 – 1000 Hz

50 ms

Auditory (Hearing) Stimulator

Number of channels

2 (Right and Left)

Stimulation level

0 – 127 dB SPL (ТА-01 phones)

0 – 130 dB SPL (TDH-39 phones)

Stimulus frequency – with Neuro-MEP.NET software

0.01 – 100 Hz

Relative deviation of stimulus frequency

within ±1 %

Stimulus duration – with Neuro-MEP.NET software

50 – 90000 µs (0.05 – 90 s)

Relative deviation of stimulus duration

within ±15%

Left/Right/Bi-lateral stimulation

yes

Photic (Vision) Stimulator

Maximum brightness of:

- LED goggles

- mini-ganzfeld stimulator

1100 ± 110 cd/m2

1500 ± 150 cd/m2

Maximum luminescence power of:

- white penlight

- red penlight

- blue penlingt

- green penlight

 

0.2 ± 0.05 cd

0.3 ± 0.075 cd

0.15 ± 0.0375 cd

0.2 ± 0.05 cd

Brightness control range

-3…0 log units

Stimulus duration – with Neuro-MEP.NET software

0.05 – 1500 ms

Relative deviation of stimulus duration

within ±10 %

Stimulus frequency – with Neuro-MEP.NET software

0.01 100 Hz

Relative deviation of stimulus frequency

within ±1 %

Left/right/Bi-lateral stimulation by LED goggles

yes

Pattern (Vision) Stimulator

Stimulation frequency – with Neuro-MEP.NET software

0.1 5 Hz

Relative deviation of stimulation frequency

within ±10%

Pattern resolution:

- standard stimulator

- high resolution stimulator

 

320 240 pixels, 15 colors

800 600 pixels, 16 million colors

General Parameters and Characteristics

Electronic Unit interface with computer

USB

Supply voltage:

- Electronic Unit

- Desktop PC-based system

- Notebook PC-based system

 

5 V DC (from USB)

 

110 V AC (60 Hz) / internal battery

Dimensions:

- Amplifier unit

- Auditory-visual stimulator unit

- Electrical stimulator control unit

 

190 x 140 x 50 mm

155 x 105 x 40 mm

155 x 105 x 40 mm

Weight:

- Amplifier unit

- Auditory-visual stimulator unit

Electrical stimulator control unit

 

not more than 1 kg

not more than 0.5 kg

not more than 0.5 kg

Safety

BF type

Transportation Conditions

Temperature

from -25 to +60°C

Humidity

20 – 95% (non-condensing)

Atmospheric pressure

from 70 kPa

Storage Conditions

Temperature

from +5 to +40°C

Humidity

30-85% (non-condensing)

Atmospheric pressure

70-106 kPa

Operation Conditions

Temperature

from +10 to +35°C

Humidity

30-85% (non-condensing)

Atmospheric pressure

70-106 kPa

     

 

Electrical Safety and Electromagnetic Compatibility

 

Electromagnetic compatibility (EMC) is ensured in compliance with the requirements of EN 60601-1-2-2015 standard.

 

The digital system is intended for operation in electromagnetic environment, which special features are specified in Annex 1.

 

The mobile radio-frequency equipment can impact the system.

 

The use of accessories not listed in Table 3 and Table 4 of this technical manual can cause the increase of electromagnetic emissions or decrease of the electromagnetic immunity.

 

As for safety, the digital system complies with the requirements of EN 60601- 1:2006/A1:2013 and EN 60601-2-40:2017 standards. The electronic unit is supplied by AC mains 220 V, 50 Hz, it has double isolation and CF type work parts according to EN 60601-1:2006/A1:2013.  All computer equipment should comply with EN 62368- 1:2014.

 

The current-impedance dependence for electrical stimulator in the range of load impedances is specified in Annex 2.

Standard Set of accessories for clinical use and experimental research:

 

Neuro-MEP-Micro/V Electronic Unit

1 pc.

USB cable, A-B type, 1,8 m

1 pc.

SH-1S Small Holder

1 pc.

Mounting bracket

1 pc.

Stimulating bar electrode SBE-2, adult

1 pc.

Cup electrode with cable, 5-pack, 1 m

1 pc.

Ring electrode with cable RE-2, wide

1 pc.

Ground electrode with cable GE-1, pediatric, 250 mm

1 pc.

Ground electrode with cable GE-2, adult, 400 mm

1 pc.

Bar electrode BE-1, pediatric

1 pc.

Surface electrode with cable SE-1

2 pcs.

Reusable cable for concentric needle electrode D60451

2 pcs.

Disposable concentric EMG needle electrode B50600, l=37 mm, d=0,45 mm

25 pcs.

Disposable concentric EMG needle electrode B50600, l=50 mm, d=0,45 mm

25 pcs.

Disposable ECG electrode F9049 22x34 mm, Fiab, Italy

100 pcs.

Cable for disposable electrode: “Alligator” clip - touch-proof, black, 0.2 m

1 pc.

Cable for disposable electrode: “Alligator” clip - touch-proof, red, 0.2 m

1 pc.

Y-adapter

1 pc.

Measuring reel

1 pc.

Marker

1 pc.

Electrode adhesive paste TEN20 , 114 g.

1 pc.

Abrasive paste for skin preparation Everi , 160 g.

1 pc.

Medical tape Transpore , 5 sm х 9.1 m

1 pc.

Technical Manual "Neuro-MEP-Micro ", ver.2009

1 pc.

Guidelines "EMG Studies Performing on Digital EMG and EP Systems"

1 pc.

Carrying Computer Case

1 pc.

License for the use of software "Neuro-MEP.NET" with additional software module "Neuro-MEP.NET/EMG"

1 pc.

License for the use of software "Neuro-MEP.NET" with additional software module "Neuro-MEP.NET/HW"

1 pc.

 

NOTE:  Computer (PC) is not included in Standard Set, but can be supplied as per Customer requirements.

 

Minimum requirements to PC:

 

· For the software based on Microsoft .NET platform dual core processor with ≥ 2.6 GHz clock rate and random-access memory (RAM) of ≥ 2 GB is required (4 GB is recommended).  For other software, the clock rate is desired to be ≥ 1200 MHz and RAM ≥ 512 MB.

 

· Either Windows 8 or Windows 10 operating system is required.  Both 32-bit and 64-bit editions are supported.

 

· A ground wire must be available as the third wire of the power outlet.  It is not allowed to connect the computers using adaptors that insulate the third wire.

 

Customized accessory sets

 

Accessory set, such as electrodes types and quantities, can be customized to specific needs of a clinic or research lab.

 

Contact us to discuss your accessory needs.

Electronic Unit limited warranty term – 2 years.

 

During the warranty term, repair is free, and if repair is impossible, Electronic Unit is replaced.  Warranty does not cover mechanical damage and unauthorized opening of Electronic Unit, and defects caused by misuse, and any product that has been altered or modified in any way.

 

Warranty repair is professionally performed at the Neurosoft Service Center in Ivanovo, RF.  Transportation costs to the Service Center are covered by the Customer, return transportation is covered by Neurosoft.

 

Customer pays return shipping charges.  We are responsible for the return shipping charges of replaced / repaired products.  Products found to be non-defective will be returned at customer's expense.

 

Extended warranty is available. Contact us for details.

 

Accessories (cables, bands, etc.) – 30 days.

 

Single-use items (electrodes, gels, pastes, etc.) are not covered.

 

Software updates are free of charge.  Please fill out the online Form to receive a download link to the version you are requesting.

Electromyography and Nerve Conduction Studies

 

Clinical application of neuromuscular electrophysiology in the dog: A review (1986)

 

Electromyography in the Horse in Veterinary Medicine and in Veterinary Research--A Review (1999)

 

Electrodiagnosis of Disorders of Neuromuscular Transmission (2013, human reference)

 

Surface electromyography in animals: A systematic review

Electromyography (2017)

 

Assessment of Neuromuscular Transmission (2013, human reference)

 

Use of Nerve Conduction Assessments to Evaluate Drug-Induced Peripheral Neuropathy in Nonclinical Species—A Brief Review (2019)

 

Neuromuscular junction testing:  Repetitive stimulation, jitter

 

Electrophysiological study in neuromuscular junction disorders (2013)

 

Evaluation of Jitter by Stimulated Single-Fiber Electromyography in Normal Dogs (2003)

 

Surface electromyography in animals: A systematic review

Electromyography (2017)

 

Neuromuscular Disorders: Myasthenia Gravis, Myopathies and More (2019)

 

Motor Unit Number Estimation (MUNE)

 

Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles (2015)

 

Blink reflex

 

Electrically Induced Blink Reflex and Facial Motor Nerve Stimulation in Beagles (2000)

 

Galvanic skin response

 

Effects of Exogenous Stimuli and Centrally Acting Drugs on Galvanic Skin Responses in Rats (1981)

 

Somatosensory Evoked Potentials (SEP)

 

Electrophysiological Assessment of Spinal Cord Function Through Somatosensory Evoked Potentials in Dogs (1999)

 

Effectiveness of Intraoperative Somatosensory Evoked Potential Monitoring During Cervical Spinal Operations on Animals with Spinal Cord Dysfunction (2005)

 

Visual Evoked Potentials (VEP)

 

Recording of Visual-Evoked Potentials in Dogs With Scalp Electrodes (1988)

 

Visual Evoked Potentials in the Clinically Normal Dog (1999)

 

Visual evoked potentials in the horse (2016)

 

Clinical Guideline for Assessing Flash Visual Evoked Potentials

in Laboratory Dogs and Normal Data for Beagle Dogs (2016)

 

Measurement of Electroretinograms and Visually Evoked Potentials in Awake Moving Mice (2016)

 

Auditory Evoked Potentials (AEP)

 

Brainstem auditory evoked response (BAER) testing in animals (2009)

 

Brainstem auditory-evoked response in dogs (2005)

 

Peaks of brainstem auditory evoked potentials in dogs (1994)

 

Vestibular Evoked Myogenic Potentials (VEMP)

 

Vestibular-evoked myogenic potentials in miniature pigs (2016)

 

Animal Models of Vestibular Evoked Myogenic Potentials: The Past, Present, and Future (2018)

 

The acoustically evoked short latency negative response (ASNR) in a unilaterally deaf cat with histologically-confirmed cochleosaccular degeneration (2020)

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